Government Scheme

BIRAC SBIRI Phase I

Small Business Innovation Research Initiative (SBIRI) Phase I grant up to ₹50 Lakh for early-stage proof-of-concept in biotech MSMEs

Early Biotech Innovation Grant

Phase I Grant

Up to ₹50 Lakh

Non-dilutive milestone grant

Project Duration

12 - 18 Months

Proof-of-concept milestone tenure

Target Entities

Biotech Startups & MSMEs

Indian companies under 500 staff

Administered By

BIRAC (Dept of Biotech)

Govt of India

About BIRAC SBIRI Phase I Scheme

The Small Business Innovation Research Initiative (SBIRI) is India's pioneer public-private partnership scheme in biotechnology, operated by BIRAC, Department of Biotechnology (DBT), Government of India.

Formulated to cultivate an innovation-driven culture among small and medium enterprises, SBIRI Phase I provides non-dilutive grant-in-aid of up to ₹50 Lakhs (covering up to 50% to 80% of project costs) to early-stage biotech startups and MSMEs for establishing proof-of-concept and validating novel technological feasibility.

The scheme covers diverse life science verticals including point-of-care medical devices, diagnostic test kits, biopharmaceuticals, agricultural bio-inputs, bio-fuels, industrial enzymes, and environmental remediation technologies.

SBIRI Phase I provides essential de-risking capital to transform high-potential biological hypotheses into tangible, validated lab prototypes, serving as the springboard to subsequent SBIRI Phase II commercial scale-up.

Key Features & National Incentives

Early-Stage Non-Dilutive Grant

Direct capital grant of up to ₹50 Lakhs distributed across 3-4 structured milestone achievements.

Proof-of-Concept De-risking

Funds raw materials, laboratory testing, cell lines, analytical assays, and pilot validation.

Academia Collaboration Option

Allows formal collaboration with premier university research laboratories with dedicated sub-budgets.

100% IP Retention

The applicant company retains complete intellectual property ownership and commercial exploitation rights.

Expert Project Mentoring

Regular technical review and guidance from domain-specialist Project Monitoring Committees.

Direct Gateway to Phase II

Successful Phase I validation grants direct eligibility for multi-crore SBIRI Phase II commercial scale-up funding.

Who Can Apply? (Eligibility Criteria)

Eligibility Rule 1

Indian registered biotech companies (Private Limited, Public Limited, or LLP) with in-house R&D facilities.

Eligibility Rule 2

At least 51% of equity shareholding must be owned by Indian resident citizens.

Eligibility Rule 3

The entity must have fewer than 500 employees (Small & Medium Enterprise definition).

Eligibility Rule 4

Must be willing to contribute the required matching promoter co-funding share.

Eligibility Rule 5

The proposed innovation must be novel and address a significant commercial or healthcare challenge.

Eligibility Rule 6

Startups under 5 years of incorporation receive relaxed eligibility requirements.

Key Benefits & Value Proposition

Benefit 1

Up to ₹50 Lakhs in non-dilutive capital to de-risk unproven early-stage biological concepts.

Benefit 2

Access to advanced testing facilities, clinical samples, and analytical instrumentation.

Benefit 3

Zero equity dilution, preserving full ownership and strategic control for founding promoters.

Benefit 4

High credibility and validation from the Department of Biotechnology enhancing investor trust.

Benefit 5

Clear pathway to secure subsequent clinical trial and manufacturing scale-up funding.

Benefit 6

End-to-end transparent digital evaluation and structured milestone fund disbursements.

Required Documents Checklist

Certificate of Incorporation, MoA / AoA, and Indian Shareholding Certificate (CA Certified).

DPIIT Recognition Certificate (for startups) / DSIR R&D Recognition (for established firms).

Detailed SBIRI Phase I Proposal with preliminary data, experimental protocol, and milestone roadmap.

Itemized Budget Breakdown with quotations for consumables and reagents.

Audited Financial Statements for past 2 years (or CA Net Worth Certificate).

Statutory Clearances (IBSC / IAEC if handling biological / animal samples).

Company Bank Account Details & Cancelled Cheque.

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