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Small Business Innovation Research Initiative (SBIRI) Phase I grant up to ₹50 Lakh for early-stage proof-of-concept in biotech MSMEs
Early Biotech Innovation Grant
Non-dilutive milestone grant
Proof-of-concept milestone tenure
Indian companies under 500 staff
Govt of India
The Small Business Innovation Research Initiative (SBIRI) is India's pioneer public-private partnership scheme in biotechnology, operated by BIRAC, Department of Biotechnology (DBT), Government of India.
Formulated to cultivate an innovation-driven culture among small and medium enterprises, SBIRI Phase I provides non-dilutive grant-in-aid of up to ₹50 Lakhs (covering up to 50% to 80% of project costs) to early-stage biotech startups and MSMEs for establishing proof-of-concept and validating novel technological feasibility.
The scheme covers diverse life science verticals including point-of-care medical devices, diagnostic test kits, biopharmaceuticals, agricultural bio-inputs, bio-fuels, industrial enzymes, and environmental remediation technologies.
SBIRI Phase I provides essential de-risking capital to transform high-potential biological hypotheses into tangible, validated lab prototypes, serving as the springboard to subsequent SBIRI Phase II commercial scale-up.
Direct capital grant of up to ₹50 Lakhs distributed across 3-4 structured milestone achievements.
Funds raw materials, laboratory testing, cell lines, analytical assays, and pilot validation.
Allows formal collaboration with premier university research laboratories with dedicated sub-budgets.
The applicant company retains complete intellectual property ownership and commercial exploitation rights.
Regular technical review and guidance from domain-specialist Project Monitoring Committees.
Successful Phase I validation grants direct eligibility for multi-crore SBIRI Phase II commercial scale-up funding.
Indian registered biotech companies (Private Limited, Public Limited, or LLP) with in-house R&D facilities.
At least 51% of equity shareholding must be owned by Indian resident citizens.
The entity must have fewer than 500 employees (Small & Medium Enterprise definition).
Must be willing to contribute the required matching promoter co-funding share.
The proposed innovation must be novel and address a significant commercial or healthcare challenge.
Startups under 5 years of incorporation receive relaxed eligibility requirements.
Up to ₹50 Lakhs in non-dilutive capital to de-risk unproven early-stage biological concepts.
Access to advanced testing facilities, clinical samples, and analytical instrumentation.
Zero equity dilution, preserving full ownership and strategic control for founding promoters.
High credibility and validation from the Department of Biotechnology enhancing investor trust.
Clear pathway to secure subsequent clinical trial and manufacturing scale-up funding.
End-to-end transparent digital evaluation and structured milestone fund disbursements.
Certificate of Incorporation, MoA / AoA, and Indian Shareholding Certificate (CA Certified).
DPIIT Recognition Certificate (for startups) / DSIR R&D Recognition (for established firms).
Detailed SBIRI Phase I Proposal with preliminary data, experimental protocol, and milestone roadmap.
Itemized Budget Breakdown with quotations for consumables and reagents.
Audited Financial Statements for past 2 years (or CA Net Worth Certificate).
Statutory Clearances (IBSC / IAEC if handling biological / animal samples).
Company Bank Account Details & Cancelled Cheque.
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Guide 2025
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